We Just Discovered Thousands of New Viruses Hiding in the Ocean
By Guillermo Dominguez Huerta, Ahmed Zayed, James Wainaina, and Matthew Sullivan
An analysis of the genetic material in the ocean has identified thousands of previously unknown RNA viruses and doubled the number of phyla, or biological groups, of viruses thought to exist, according to a new study our team of researchers has published in the journal Science.
RNA viruses are best known for the diseases they cause in people, ranging from the common cold to COVID-19. They also infect plants and animals important to people.
These viruses carry their genetic information in RNA, rather than DNA. RNA viruses evolve at much quicker rates than DNA viruses do. While scientists have cataloged hundreds of thousands of DNA viruses in their natural ecosystems, RNA viruses have been relatively unstudied.
Unlike humans and other organisms composed of cells, however, viruses lack unique short stretches of DNA that could act as what researchers call a genetic barcode. Without this barcode, trying to distinguish different species of virus in the wild can be challenging.
To get around this limitation, we decided to identify the gene that codes for a particular protein that allows a virus to replicate its genetic material. It is the only protein that all RNA viruses share, because it plays an essential role in how they propagate themselves. Each RNA virus, however, has small differences in the gene that codes for the protein that can help distinguish one type of virus from another.
So we screened a global database of RNA sequences from plankton collected during the four-year Tara Oceans expeditions global research project. Plankton are any aquatic organisms that are small to swim against the current. They’re a vital part of ocean food webs and are common hosts for RNA viruses. Our screening ultimately identified over 44,000 genes that code for the virus protein.
Our next challenge, then, was to determine the evolutionary connections between these genes. The more similar two genes were, the more likely viruses with those genes were closely related. Because these sequences had evolved so long ago (possibly predating the first cell), the genetic signposts indicating where new viruses may have split off from a common ancestor had been lost to time. A form of artificial intelligence called machine learning, however, allowed us to systematically organize these sequences and detect differences more objectively than if the task were done manually.
We identified a total of 5,504 new marine RNA viruses and doubled the number of known RNA virus phyla from five to 10. Mapping these new sequences geographically revealed that two of the new phyla were particularly abundant across vast oceanic regions, with regional preferences in either temperate and tropical waters (the Taraviricota, named after the Tara Oceans expeditions) or the Arctic Ocean (the Arctiviricota).
We believe that Taraviricota might be the missing link in the evolution of RNA viruses that researchers have long sought, connecting two different known branches of RNA viruses that diverged in how they replicate.
These new sequences help scientists better understand not only the evolutionary history of RNA viruses but also the evolution of early life on Earth.
As the COVID-19 pandemic has shown, RNA viruses can cause deadly diseases. But RNA viruses also play a vital role in ecosystems because they can infect a wide array of organisms, including microbes that influence environments and food webs at the chemical level.
Mapping out where in the world these RNA viruses live can help clarify how they affect the organisms driving many of the ecological processes that run our planet. Our study also provides improved tools that can help researchers catalog new viruses as genetic databases grow.
Despite identifying so many new RNA viruses, it remains challenging to pinpoint what organisms they infect. Researchers are also currently limited to mostly fragments of incomplete RNA virus genomes, partly because of their genetic complexity and technological limitations.
Our next steps would be to figure out what kinds of genes might be missing and how they changed over time. Uncovering these genes could help scientists better understand how these viruses work.https://counter.theconversation.com/content/180545/count.gif?distributor=republish-lightbox-advanced
Guillermo Dominguez Huerta, Ahmed Zayed, James Wainaina, and Matthew Sullivan are microbiologists at The Ohio State University.
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איתך כלום, כל מה שאתה צריך לעיסוי מפנק נמצא בשפע.
תוספות לעיסוי מקצועי – אם בא לכם לשדרג את העיסוי שלכם באבנים חמות או אמבטיית מלח, תצטרכו לשלם עוד
על כל התענוג הזה. אבנים חמות – טיפול מגע עתיק יומין,
שמספק לכם חוויה מיוחדת – עיסוי בעזרת אבנים טבעיות,
חמות, חלקות ונעימות למגע, שמסייעות למטפל לחדור לעומק השריר ולהרפות איברים
כואבים. העיסוי באבנים חמות משמש גם כטיפול וגם כפינוק , יתרון גדול יש לאבנים חמות שניתן לשים אותם
על העצמות ובמיוחד בעמ״ש ע״י החום אפשר לטפל בכאבים באצמות מה שלא ניתן לעשות
בעיסוי . יש כמה דברים שכדאי לשים
לב אליהם כאשר מזמינים עיסוי אירוטי בעיר גדולה כמו אשקלון.
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הזמן לבקר בפורטל שלא מתפשר על שום נערה ונערה ומביא את המודעות השוות
ביותר בעיר תחת מעטה של פרטיות, עונג וכל מה שביניהם.
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האזור. חלקן הגדול של נערות הליווי בחיפה מתגוררות בעיר, להבדיל מהעיר תל אביב למשל, אשר מרבית הבחורות הגיעו לחופשה זמנית.
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לחץ ואף למדנו בקושי לשים לב עד כמה העצבים שלנו מתוחים.
לאזור התמיכה הקשה בעזרת לחץ מהיר.
עיסויים אלו מתאימים במיוחד לבני זוג שרוצים
להפתיע או לבלות יחד ערב רומנטי
וקסום, להירגע ולחוות אינטימיות בדרך נעימה ומקרבת.
הדירות הדיסקרטיות ברחובות ממוקמות ברחבי העיר ומשמשות כמוקד למתן שירותי עיסוי ופינוק ולהתייחדות של בני זוג.
עיסוי הכי טוב באשקלון .מזמינה אותכם להתפנק בקליניקה
פרטית. בוקר טוב. אשמח להזמין עיסוי זוגי לגבעתיים.העניין שאני
לא ממש מבינה בסוגים השונים, אשמח להלמצות לגבי סוגי עיסויים לזוג שלא ממש מבין.
עיסוי מתיחת שרירים, רצועות, פאסיה, מפרק מתיחה מתבצעת לאחר המישוש.
היעלמות הכאב, הסרת עווית שרירים, עלייה בנפח התנועה, לאחר מניפולציה נכונה, השפעה זו אינה נמשכת זמן רב ונדרשת
מניפולציות חוזרות ונשנות.
מבחינה היסטורית, מניפולציה על המפרקים נחשבה לבסיס הטיפול הידני.
לכן, נסיגת הבקע אינה נכללת
לחלוטין בהתבסס על חוקי הביומכניקה על פי תפיסות מודרניות, יש להפחית באופן משמעותי את שיעור הטכניקות המניפולטיביות בארסנל של אמצעים שונים
לטיפול ידני.
כשהמעסה מגיע אליכם, אתם יכולים מיד בתום העיסוי
להתפנק ברחצה בחדר האמבט הפרטי שלכם.
כשאתם מתעניינים לגבי עיסוי במרכז,
דעו כי פתוחות בפניכם שתי אפשרויות עיקריות:
עיסוי ברחובות המתבצע בבית הפרטי שלכם או עיסוי ברחובות המתבצע בקליניקה פרטית.
מנגד, כל עוד תקבלו עיסוי בבאר שבע בלבד
לאורך כ-45 דקות ועד שעה, המחיר שתצטרכו לשלם יהיה נוח הרבה יותר ויהפוך
את חווית העיסוי לנגישה גם לכם.
מסאז׳ מקצועי בנתניה/השרון הטיפולי דומה לזה מרגיע,
קלאסי – הוא גם מאיץ את הדם, מסלק מלחציים בשרירים, משפר את זרימת הדם ואת זרימת
הלימפה. ההבדל העיקרי הוא שעיסוי קלאסי משפיע רק על העור והשרירים, בעוד שהטיפול הטיפולי
עובד עמוק יותר, ומשפיע על מערכות הדם, העצבים והלימפה ואיברים פנימיים.
בעוד העיסויים הקלאסיים יותר מתבצעים על
מיטת טיפולים או על מזרן מוגבה, עיסויים בצפון
אלו לרוב נערכים בגובה הרצפה על מזרן.
מעוניינים בדיל של צימר עם ארוחת בוקר ברמת הגולן, טיול ג’יפים בצפון בנהיגה עצמית ולבסוף, לבקר בערב במסעדה טובה?
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ישנן נערות ממדינות שונות בעלות מראה והופעה שונה; כל גבר יכול למצוא את הנערה המתאימה לפנטזיה שלו – מבהירות שיער וכהות ועד עיסוי אירוטי גינג׳יות
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תגיע עד אלייך אמילייה לביתך/ מלון נמרה אמתית מחפשת נדיב ומיוחד.
בחדרים תמצאו מיטות עם מצעים נקיים,
מגבות וסבונים במקלחת ורמה גבוהה מאוד ממש כמו בבתי מלון.
באתר מעסים תמצאו את המעסה המתאימה
לכם ביותר ולפי אזור מגוריכם. מדובר על
עיסוי במרכז הניתן משני מעסים שונים, כאשר כל מעסה מתמקד בחלק אחר בגוף.
הצוות שלנו מסור, מסירות היא חלק
מהעבודה שלנו בתור מעסים. לכמה שעות
ארוכות תוכלו לשכוח מכל מי שמסביבכם, מכל הצרות, מכל הסידורים, מהעבודה ומכל
דבר אפשרי ורק להתרכז בעצמכם,
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תוכלו להגיע לבד, עם בני/בנות הזוג או עם חברים.
דרך זו תאפשר לכם להספיק הרבה יותר, כאשר הזמן שנחסך יופנה לטיפול בעבודות הבית,
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במתחם הספא היוקרתי והמומלץ שלנו תוכלו
ליהנות מסוגי טיפולים שונים, החל מעיסויים קלאסיים, דרך
עיסויים מיוחדים ועד עיסוי טנטרי.
סוג הבעיה – לא משנה אם יש לכם כאב
ראש, כאבי שרירים, פריצת דיסק, בעיות במערכת העיכול או מתח נפשי, סוג הכאב
שאתם חווים – לא ייקר את העיסוי.
קינק סוויט חדרים להשכרה בבאר
שבע לפי שעה מתחם אירוח דיסקרטי וחדדש, מושקע, מפואר ומעוצב
בדיוק כמו שאתם אוהבים ובמחיר מפתיע.
במכון סול, קיימים מספר מיקומים במרכז הארץ ובשפלה
להשכרת מרחבים טיפוליים, על פי חדרים שלמים או ססיות.
וילה אגם – וילה לאירועים פרטיים במרכז הארץ.
גריי אירועים הממוקם ביהוד,
מוכר בעיקר כמקום להופעות, אך
זה גם מקום לאירועים קטנים במרכז.
החדרים לפי שעה באשדוד מעוצבים ברמה גבוה ומציעים לכם מקום מפלט מפנק..
אולפן הקלטות מקצועי שמתמחה בהפקה וסאונד ברמה הגבוהה ביותר.
טניה נערת ליווי אוקראינית ברמה ממש גבוהה.
עיסוי בירושלים עד הבית מהמעסים המובחרים, בעלי מקצועיות
גבוהה עם ניסיון רב שנים. יש אתרי ספא בירושלים בבתי המלון השונים
והמרהיבים בעיר וגם אתרי ספא פרטיים.
לוד הינה עיר הנמצאת במרכז הארץ, בעיר מתגוררים יהודים,
מוסלמים ונוצרים, מיקומה הנהדר בלב ליבה של מדינת ישראל מאפשרים לנופשים זמינות לכל מקום, נוחות
ואיכות חיים גבוה.
ישנם אנשים שלא מרגישים בנוח שבן המין השני נוגע בהם, כך שחשוב לתאם מראש עם מכון העיסוי מפנק בקרית שמונה/נהריה את מין המעסה.
עיסוי מפנק בקרית שמונה/נהריה לגוף והנפש, משחרר
מתח, רגשות שליליים וגירוי, שהם המלווים המחייבים כמעט של
כל האנשים בעולם הנוכחי.
הבחורה הכי מפנקת בעיר מזמינה אותך
לעיסוי מפנק בביתה הפרטי בחורה יפיפייה עם גוף מהסרטים… עיסוי מאישה חטובה ויפה בבאר שבע בבית הפרטי שלה,
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שבע נחשבת לבירת הנגב, מעבר לעובדה שמדובר בעיר הגדולה יותר באזור.
לאור ההתפתחות הגדולה של ענף הדירות הדיסקרטיות שמציע מבחר גדול של דירות דיסקרטיות ברחבי הארץ,
נוצר רצון לתת מענה לכל דורש. ההמלצה הגדולה של הבנות של דירות דיסקרטיות הוא הצורך לדבר
במהלך העיסוי ובעיקר אחריו.
לרוב, הטיפול נערך על מיטת עיסוי מיוחדת, שמאפשרת לנשים בהיריון לנוח בחופשיות ולהרגיש נינוחות במהלך העיסוי
המפנק. במהלך הטיפול יפעיל המטפל לחץ על
נקודות לאורך כפות הרגליים תוך
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בשיטות שונות, תוכלו בהחלט לשאול אותם לגבי עיסוי ארוטי בבית שמש ואם הם אכן
מכירים מקום כזה, סביר להניח שזה יהיה מקום מקצועי שייתן לכם שירות טוב.
במקרים רבים אלו יכולים להיות אפילו אנשים נשואים אשר יש להם משפחה ולמרות זאת הם מתמודדים
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החופש והשלווה שרבים מאיתנו כל כך אוהבים,
בכלל שרצינו לתת לכם את ההרגשה שאתה תמיד “יכולים להרגיש פוקט” גם פה שאתם בישראל.
עדינה ויפייפיה, חדשה בישראל.
כאן המודעות הן הכי מעודכנות ויש סיכוי
טוב שתוכלו להזמין פה נערת ליווי חדשה בתחום, להבדיל מאתרים אחרים.
הקליקו כבר עכשיו ומצאו את נערת חלומותיכן תחת .
כנס כבר עכשיו לאתר ותאתר
את הבחורה שתהיה איתך ממש בעוד כמה שעות.
בעוד שחלק מהטיפולים מתמקדים בכל מה שקשור
לעולם היופי והאסתטיקה, טיפולים אחרים
מתבססים על עיסויים מקצועיים במגוון שיטות ועל ידי מעסים מוסמכים בלבד.
בקליניקה ניתן ליהנות ממגוון עיסויים
וטיפול ניקוי רעלים באמצעות חליפת פרסותרפיה.
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Pharmacology’s Role and Drug Development in Modern Society
Pharmacology, the science of drugs and their effects on living systems, plays a pivotal role in modern society. With an ever-increasing burden of diseases and health conditions, the development of new medications is vital for improving healthcare outcomes and enhancing quality of life. This article explores the significance of pharmacology and the process of drug development in addressing contemporary health challenges.
**Understanding Pharmacology:**
Pharmacology encompasses a multidisciplinary approach, combining aspects of biology, chemistry, physiology, and pathology to study how drugs interact with biological systems. It delves into the mechanisms of action, therapeutic effects, and potential side effects of medications. By comprehensively understanding these factors, pharmacologists strive to develop safer and more effective drugs for treating various ailments.
**Importance of Drug Development:**
The development of new drugs is essential for combating both prevalent and emerging health threats. Chronic diseases such as cardiovascular disorders, cancer, diabetes, and respiratory ailments continue to impose a significant burden on global health. Moreover, the emergence of novel pathogens, antimicrobial resistance, and environmental factors further underscore the need for innovative pharmaceutical solutions.
**Phases of Drug Development:**
The journey from drug discovery to market availability is a complex and rigorous process comprising several distinct phases:
1. **Drug Discovery:** Scientists identify potential drug candidates through various means, including screening natural compounds, designing molecules using computational methods, or repurposing existing drugs for new indications.
2. **Preclinical Research:** Promising drug candidates undergo extensive laboratory testing to assess their safety, efficacy, and pharmacokinetic properties in cellular and animal models.
3. **Clinical Trials:** Drug candidates that demonstrate favorable preclinical results advance to clinical trials, which consist of three sequential phases:
– **Phase I:** Involves testing the drug’s safety and dosage in a small group of healthy volunteers.
– **Phase II:** Evaluates the drug’s efficacy and side effects in a larger group of individuals with the targeted disease or condition.
– **Phase III:** Further assesses the drug’s safety and efficacy in a diverse population across multiple locations to establish its therapeutic benefits and risks.
4. **Regulatory Approval:** Following successful completion of clinical trials, pharmaceutical companies submit comprehensive data to regulatory authorities such as the FDA in the United States or the EMA in Europe for approval to market the drug.
5. **Post-Marketing Surveillance:** Even after approval, ongoing monitoring is crucial to detect any unforeseen adverse effects and ensure the drug’s continued safety and efficacy in real-world settings.
**Challenges and Future Directions:**
Despite significant advancements in pharmacology and drug development, several challenges persist. These include escalating research and development costs, regulatory hurdles, ethical considerations, and the increasing complexity of diseases. Additionally, disparities in access to medications and healthcare services remain a global concern.
Looking ahead, emerging technologies such as precision medicine, gene editing, and artificial intelligence offer promising avenues for personalized therapies and targeted drug development. Collaborative efforts among researchers, clinicians, pharmaceutical companies, and policymakers are imperative to address these challenges and harness the full potential of pharmacology in improving global health outcomes.
In conclusion, pharmacology plays a central role in modern society by driving the development of new medications to combat a myriad of health challenges. Through continuous innovation and collaboration, the field of pharmacology holds immense promise for enhancing healthcare delivery and promoting well-being worldwide.
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ГГУ имени Ф.Скорины
One of the leading academic and scientific-research centers of the Belarus. There are 12 Faculties at the University, 2 scientific and research institutes. Higher education in 35 specialities of the 1st degree of education and 22 specialities.
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When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get four emails with the same comment. Is there any way you can remove me from that service? Bless you!
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